At age nine Mila Kunis was enrolled by her father in acting classes after school at the Beverly Hills Studios, where she met Susan Curtis, who would become her manager. On her first audition she landed the role for a Barbie commercial. Shortly after, she did a commercial for the Lisa Frank product line. Her first television roles took place in 1994, first appearing on Days of Our Lives, and a few months later doing her first of two appearances on Baywatch. She had a minor role on 7th Heaven and supporting roles in Santa with Muscles, Honey, We Shrunk Ourselves, and the Angelina Jolie film Gia, as the young Gia Carangi.
At the age of 10, Kunis auditioned for but failed to get the role of a Russian Jewish girl who moves to America in the film Make a Wish, Molly. Instead, she was cast in the secondary role of a Mexican girl.
In 1998, Kunis was cast as Jackie Burkhart in the Fox sitcom That ’70s Show. All who auditioned were required to be at least 18 years old; Kunis, who was 14 at the time, told the casting directors she would be 18 but did not say when. Though they eventually figured it out, the producers still thought Kunis was the best fit for the role. That ’70s Show ran for eight seasons. She won two consecutive Young Star Awards as Best Young Actress in a Comedy TV Series in 1999 and 2000 for her performances.
In 1999, Kunis replaced Lacey Chabert in the role of Meg Griffin on the animated sitcom Family Guy, created by Seth MacFarlane for Fox. Kunis won the role after auditions and a slight rewrite of the character, in part due to her performance on That ’70s Show. MacFarlane called Kunis back after her first audition, instructing her to speak slower, and then told her to come back another time and enunciate more. Upon claiming that she had mastered these speech particulars, MacFarlane hired her. MacFarlane added: “What Mila Kunis brought to it was in a lot of ways, I thought, almost more right for the character. I say that Lacey did a phenomenal job, but there was something about Mila – something very natural about Mila. She was 15 when she started, so you were listening to a 15-year-old. Often times with animation they’ll have adult actors doing the voices of teenagers and they always sound like Saturday morning voices. They sound often times very forced. She had a very natural quality to Meg that really made what we did with that character kind of really work.” Kunis was nominated for an Annie Award in the category of Voice Acting in an Animated Television Production in 2007. She also voiced Meg in the Family Guy Video Game!. Kunis described her character as “the scapegoat.”